{"id":9122,"date":"2013-02-16T13:28:13","date_gmt":"2013-02-16T18:28:13","guid":{"rendered":"https:\/\/crashingpatient.com\/?p=9122"},"modified":"2013-02-16T13:28:13","modified_gmt":"2013-02-16T18:28:13","slug":"extracorporeal-removal-techniques-in-toxicology","status":"publish","type":"post","link":"https:\/\/crashingpatient.com\/toxicology\/extracorporeal-removal-techniques-in-toxicology.htm\/","title":{"rendered":"Extracorporeal Removal Techniques in Toxicology"},"content":{"rendered":"<p>From (J Intensive Care Med 2012;25(3):139)<\/p>\n<h3>Characteristics of Xenobiotics That Are Cleared by ECR<\/h3>\n<p><strong>For all 3 techniques<\/strong><\/p>\n<ul>\n<li>Low volume of distribution (Vd; &lt;1 L\/kg), that is, not in tissue<\/li>\n<li>Single-compartment kinetics<\/li>\n<li>Low endogenous clearance (&lt;4 mL\/min per kilogram)<\/li>\n<\/ul>\n<p><strong>For hemodialysis<\/strong><\/p>\n<ul>\n<li>MW &lt;500 Da (little data on high-flux membranes)<\/li>\n<li>Water soluble<\/li>\n<li>No plasma protein binding<\/li>\n<\/ul>\n<p><strong>For hemoperfusion<\/strong><\/p>\n<ul>\n<li>Must be adsorbed by activated charcoal<\/li>\n<\/ul>\n<p><strong>For hemofiltration<\/strong><\/p>\n<ul>\n<li>Higher MW, 1000 to 4000 Da, depending on the membrane<\/li>\n<\/ul>\n<p>NOTES: ECR=extracorporeal removal; MW=molecular weight.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>From (J Intensive Care Med 2012;25(3):139) Characteristics of Xenobiotics That Are Cleared by ECR For all 3 techniques Low volume of distribution (Vd; &lt;1 L\/kg), that is, not in tissue Single-compartment kinetics Low endogenous clearance (&lt;4 mL\/min per kilogram) For hemodialysis MW &lt;500 Da (little data on high-flux membranes) Water soluble No plasma protein binding [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[10],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - 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