From (J Intensive Care Med 2012;25(3):139)
Characteristics of Xenobiotics That Are Cleared by ECR
For all 3 techniques
- Low volume of distribution (Vd; <1 L/kg), that is, not in tissue
- Single-compartment kinetics
- Low endogenous clearance (<4 mL/min per kilogram)
For hemodialysis
- MW <500 Da (little data on high-flux membranes)
- Water soluble
- No plasma protein binding
For hemoperfusion
- Must be adsorbed by activated charcoal
For hemofiltration
- Higher MW, 1000 to 4000 Da, depending on the membrane
NOTES: ECR=extracorporeal removal; MW=molecular weight.
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