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You are here: Home / 14. Toxicology / Extracorporeal Removal Techniques in Toxicology

Extracorporeal Removal Techniques in Toxicology

February 16, 2013 by CrashMaster

From (J Intensive Care Med 2012;25(3):139)

Characteristics of Xenobiotics That Are Cleared by ECR

For all 3 techniques

  • Low volume of distribution (Vd; <1 L/kg), that is, not in tissue
  • Single-compartment kinetics
  • Low endogenous clearance (<4 mL/min per kilogram)

For hemodialysis

  • MW <500 Da (little data on high-flux membranes)
  • Water soluble
  • No plasma protein binding

For hemoperfusion

  • Must be adsorbed by activated charcoal

For hemofiltration

  • Higher MW, 1000 to 4000 Da, depending on the membrane

NOTES: ECR=extracorporeal removal; MW=molecular weight.

 

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Filed Under: 14. Toxicology


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