Crashing Patient

  • Home
  • EMCrit Blog
  • Index
  • Contact
You are here: Home / 09. Medical/Surgical / cardiology / Pulmonary Hypertension

Pulmonary Hypertension

July 14, 2011 by CrashMaster

Review Article

best: (Crit Care Med 2007;35:2037)

 

 

(Clinical Pulmonary Medicine 2004;11(1):40)

 

Cor pulmonale is pulmonary hypertension in the setting of respiratory disease either acute or chronic, it does not require right heart failure thought that is sometimes a sequelae

 

Divided into primary, which is idiopathic (PPH or IPH) and secondary, from a cause outside of the lung vasculature.

 

While acute disease may be reversible, vascular remodeling in chronic disease may be permanent

 

PPH

unknown etiology, there have been associations with amphetamine diet aids, contaminated rapeseed oil, and contaminated l-tryptophan.

 

Patients present with substernal chest pain or pressure, exertional dyspnea, fatigue, and possibly syncope.

Diagnostics

Chest x-ray will show prominent pulmonary arterial vasculature

ECG will may show right ventricular hypertrophy

 

High resolution CT, Perfusion nuclear scanning, MRI, and angiography may all be useful.  Cardiac cath may be needed as well.  Lung biopsy may be a final, necessary step to make a diagnosis of cause for PH.

 

Therapy

Correct hypoxemia

PaO2<55 or PaO2<59 with Crit>55, p pulmonale, or edema should be treated with chronic supplemental O2

CCBs, Iv nitroglycerin, IV Prostacyclin, epoprostenol (Flolan), eventual lung transplantation

vasodilator therapy is not without risks as it can cause systemic hypotension or worsen PH b/c if the pulmonary diameter is fixed, it will just cause decreased RH pressures without affecting pulmonary.

 

at risk for venous thromboembolic disease

chronic VTE can also be the cause of pulmonary hypertension and often the patient will have dramatic improvement if the clot is removed

Estimation of Mean Pulmonary Artery Pressure

(Chest. 2008; 133:592-593)

An invasive study by our team1 has challenged this model by reporting that sPAP accounts for 98% of mPAP variability in resting humans studied over à range of 10 to 78 mm Hg, and that a new formula (mPAP = 0.61 sPAP + 2) reasonably predicts mPAP, with a 0 ± 2 mm Hg bias (mean ± SD). Our retrospective analysis1 of the pressure data previously published by Laskey et al2 led to similar conclusion. The principle that underlies scientific modeling cautions against favoring the complex models over the simple ones,3 and this favors the use of sPAP only to estimate mPAP, without the need to include dPAP in the model. Although initially challenged,4 our findings have been confirmed in children free of congenital heart diseases,5 and have proved useful to estimate mPAP in large-scale studies performed in both adults6 and children7 for whom only Doppler-derived sPAP data are available. Finally, a linear relationship between mPAP and sPAP has also been documented in pulmonary arterial hypertension patients performing graded, submaximal supine exercise both before and after a 6-week prostacyclin treatment.8

 

HIV

can cause pulmonary hypertension

 

PAH associated with syncope, vasovagal, and sudden death

 

hypoxemia and hypercarbia are both vasoconstrictors

 

sleep apnea to pulm htn to apnea to worsening pulm htn

 

coumadin o2 diuretics

Hanging Flolan using normal IV pump

1.        Get Intervia (empty IV bag) and light proof plastic bag.

2.        Mix Flolan with sterile diluent

3.        Inject Flolan into intervia

4.        Place Ice on both sides in light-proof bag

5.        Use normal IV tubing, no filter required.

6.        Convert pt’s 24 hour rate to hourly rate

 

 

 

|      |      |

Share this:

  • Print
  • Email

Filed Under: cardiology, pulmonology


Creative Commons License 2012. This site represents the opinions of Crashing Patient LLC. See here for full disclaimer.

© 2023 ·